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Glyphosate - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information

Note: See Working with the Information on this Page section below for important notes about this data.

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Chemical ID
 Identifying information, including synonyms, ID numbers, use type, chemical classification, a link to a list of all products containing this chemical and a list of the top crops this pesticide is used on in California.
Poisoning Symptoms
 Signs and symptoms of poisoning, first aid, and links to treatment information for this chemical.
Toxicity
 Link to information on toxicity to humans, including carcinogenicity, reproductive and developmental toxicity, neurotoxicity, and acute toxicity.
Regulatory
 Links to world-wide registration status as well as regulatory information for the U.S. and California.
Water
 Water quality standards and physical properties affecting water contamination potential.
Ecotoxicity
 Toxicity to aquatic organisms.
Related Chems
 List of chemicals in the same family, including breakdown products, salts, esters, isomers, and other derivatives.
 

Chemical Identification and Use for Glyphosate
Basic Identification Information About This Chemical
Chemical Name: Glyphosate
CAS Number: 1071-83-6
U.S. EPA PC Code: 417300
471300 (Old US EPA PC Code.)
CA DPR Chem Code: 2997
Molecular Weight: 169.1
Molecular Structure:
Use Type: Herbicide
Chem Class: Phosphonoglycine
View Related Chemicals
 
Additional Resources About This Chemical Class and Use Type

See the Global Pesticide Resources page for many additional links.
Historical Use of this Chemical
Top five crops and sites for this pesticide in California
Almonds   Pistachios   Oranges   Pomegranates   Right of Way  
View All Crops and Sites
 
Other Names for this Chemical
About Chemical Synonyms
02997 (CA DPR Chem Code Text) , 02997 (CA DPR Chem Code) , 1071-83-6 (CAS number) , 1071836 , 1071836 (CAS number without hyphens) , 2997 (CA DPR Chem Code) , 2997 (CA DPR Chem Code) , 417300 (US EPA PC Code Text) , 417300 (US EPA PC Code) , 471300 (Old US EPA PC Code) , 471300 (US EPA PC Code Text) , 471300 (US EPA PC Code) , CP 67573 , Glifosate , Glifosato , Glifoz?t , Glycine, N-(phosphonomethyl)- , Glyfosaat , glyfosat , Glyphosat , Glyphosate , Glyphosate , Glyphosate (ANSI) , Glyphosate acid , glyphosate acide , Glyphosphate , N-(Phosphonomethyl)glycine , Round-up , Roundup , Use code no. 417300
 
Products Containing This Chemical
Current and historic U.S. registered products
View U.S. Products All Products Currently Registered Products
 

Signs and Symptoms of Glyphosate Poisoning

NOTE! There may be other diseases and chemicals that have similar symptoms.

If you have a poisoning emergency in the United States call 1-800-222-1222.
If the victim has collapsed or is unconscious, call 911.

Glyphosate is a Glyphosate compound.

Report a Poisoning
Symptoms of Poisoning with Glyphosate Compounds
Find Products Containing this Chemical

- Formulations may show moderate toxicity.
- The trimethylsulfonium salt causes eye irritation in rabbits; some formulations may cause much more extreme irritation of the skin or eyes.
- Some formulations may show high acute inhalation toxicity.

Source for Group Symptoms: Extension Toxicology Network (EXTOXNET), Oregon State University. June 1996.
Treatment for Glyphosate Poisoning

See: Recognition and Management of Pesticide Poisoning, 5th edition, U.S. EPA, Chapter 13. March 1999.

 
Symptoms of Glyphosate Exposure from the International Chemical Safety Cards (ICSC)

Report a Poisoning
View full ICSC Cards: English   Español   Française   Chinese   Dutch   Finnish   German   Hungarian   Japanese   Swahili   Thai   Urdu  
NOTE! PREVENT DISPERSION OF DUST!

Route of Exposure

Symptoms

First Aid
Inhalation Cough. (See Ingestion). Fresh air rest. Refer for medical attention.
Skin Rinse skin with plenty of water or shower.
Eyes Redness. First rinse with plenty of water for several minutes (remove contact lenses if easily possible) then take to a doctor.
Ingestion Diarrhoea. Shortness of breath. Vomiting. Weakness. Rinse mouth. Refer for medical attention.
Notes for ICSC Information
The alkali metal and amine salts are readily soluble in water. Carrier solvents used in commercial formulations may change physical and toxicological properties. Roundup (for the monoisopropylammonium salt) and Polado (for the sesquisodium salt) are trade names.
Symptoms of Glyphosate Exposure from Other Sources

- Formulations may show moderate toxicity.
- The trimethylsulfonium salt causes eye irritation in rabbits; some formulations may cause much more extreme irritation of the skin or eyes.
- Some formulations may show high acute inhalation toxicity.

Source for Symptoms: Extension Toxicology Network (EXTOXNET), Oregon State University. June 1996. (ExToxNet)

First Aid for Glyphosate Poisoning

No first aid available for this particular chemical. Get medical aid.

Source for First Aid: ()

 
 

Toxicity Information for Glyphosate

  Note: Information for many chemicals is incomplete and may not be fully representative of effects on humans. Why?

Summary Toxicity Information

PAN Bad Actor
Chemical 1 		Acute
Toxicity 2 		Carcinogen Cholinesterase
Inhibitor 		Ground
Water Contaminant 		Developmental or
Reproductive Toxin 		Endocrine
Disruptor
Not Listed Slight Not Likely No Potential
 
Indicates high toxicity in the given toxicological category. Indicates no available weight-of-the-evidence summary assessment. For additional information on toxicity from scientific journals or registration documents, see the "Additional Resources for Toxicity " section of the chemical detail page.
1. PAN Bad Actors are chemicals that are one or more of the following: highly acutely toxic, cholinesterase inhibitor, known/probable carcinogen, known groundwater pollutant or known reproductive or developmental toxicant. NOTE! Because there are no authoritative lists of Endocrine Disrupting (ED) chemicals, EDs are not yet considered PAN Bad Actor chemicals.
2. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above.

Additional Resources about the Toxicity of this Chemical

See the Global Pesticide Resources page for many additional links.

Detailed Toxicity Information
Acute Toxicity 2
 Glyphosate
WHO Acute Hazard
TRI Acute Hazard
Material Safety Data Sheets
Acute rating from U.S. EPA product label
U.S. NTP Acute Toxicity Studies
      View Studies
Cholinesterase Inhibitor		 U, Unlikely to be Hazardous
Not Listed
Not Available

Not Acutely Toxic to Slightly Toxic

No
2. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above.
 
Cancer Information
 Glyphosate
IARC Carcinogens
U.S. NTP Carcinogens
California Prop 65 Known Carcinogens
U.S. EPA Carcinogens
TRI Carcinogen		 Not Listed
Not Listed
Not Listed
E, Unlikely
Not Listed
 
Endocrine Disruption
 Glyphosate
Illinois EPA list
Keith list
Colborn list
Benbrook list
Danish Inert list
EU list		 Not Listed
Not Listed
Not Listed
Not Listed
Not Listed
Not Listed
 
Reproductive and Developmental Toxicity
 Glyphosate
CA Prop 65 Developmental Toxin
U.S. TRI Developmental Toxin
CA Prop 65 Female Reproductive Toxin
CA Prop 65 Male Reproductive Toxin
U.S. TRI Reproductive Toxin 		Not Listed
Not Listed
Not Listed
Not Listed
Not Listed
 
Chemicals of Special Concern
 Glyphosate
PAN Bad Actors
PAN Dirty Dozen list		 Not Listed
Not Listed
 

Water Pollution Potential and Criteria for Glyphosate

Water Pollution Potential

PAN Ground Water Contaminant Rating Potential
 
Physical Property Data Related to Water Contamination Potential
Water Solubility (Avg, mg/L)
Adsorption Coefficient (Koc)
Hydrolysis Half-life (Avg, Days)
Aerobic Soil Half-life (Avg, Days)
Anaerobic Soil Half-life (Avg, Days) 		11,600
6,920
35.0
96.0
22.0 		 
 

Water Standards and Criteria
U.S. National Drinking Water Standards and Health Criteria
 µg/L unless noted  
Maximum Contaminant Level (MCL) 700.0  
Maximum Contaminant Level Goal (MCLG) 700.0  
One Day Exposure Health Advisory Level 20,000  
Ten Day Exposure Health Advisory Level 20,000  
Lifetime Exposure Health Advisory Level  
Reference Dose 2,000 (µg/kg/day)  
U.S. Drinking Water Equivalent Level 70,000  
Concentration with Lifetime Cancer Risk of 1 in 10,000  
Canada Drinking Water Standards and Criteria
 µg/L unless noted  
Maximum Acceptable Concentration (MAC) 280.0
Interim Maximum Acceptable Concentration (IMAC)
Aesthetic Objectives
Canadian Water Quality Guidelines for the Protection of Aquatic Life
 µg/L unless noted  
Fresh Water Guidelines 65 Notes: c
Salt Water Guidelines
Canadian Water Quality Guidelines for the Protection of Agricultural Water Uses
 µg/L unless noted  
Irrigation Water Guidelines
Livestock Water Guidelines 280
 

Regulatory Information for Glyphosate

International Regulatory Status
Registration in Selected Countries Registration in Selected Countries:
Glyphosate
 
UNEP Persistent Organic Pollutant (POP)
UNEP Prior Informed Consent Chemical (PIC)
WHO Obsolete Pesticide		 Not Listed
Not Listed
Not Listed
 

U.S. and California Regulatory Status
U.S. EPA Registered
U.S. EPA Hazardous Air Pollutant
U.S. EPA Minimum Risk Pesticide (25b list)

CA Registered
CA Groundwater Contaminant
CA Toxic Air Contaminant 		Yes
Not Listed
No

Yes
Not Listed
Not Listed
 

Maximum Tolerance and Residue Levels
Codex Alimentarius
   (UN FAO Maximum Residue Limits)
U.S. Maximum Tolerance Levels
European Union Maximum Residue Levels 		Go to web site

Go to web site
Go to web site
 

Ecotoxicity for Glyphosate

Note! Information for many chemicals is incomplete and may not be fully representative of effects on the environment. Why? Click on underlined terms for definitions and additional information.

Aquatic Ecotoxicity
All Toxic Effects for Organism Group
Organism Group Effects Noted
Amphibians Biochemistry, Development, Genetics, Growth, Morphology, Mortality
AquaticPlants Accumulation, Biochemistry, Development, Growth, Morphology, Mortality, Physiology, Population
Crustaceans Mortality
Echinoderms Development
Fish Accumulation, Avoidance, Biochemistry, Enzyme(s), Growth, Histology, Immunological, Intoxication, Mortality
Insects Intoxication, Population
Molluscs Behavior, Development, Enzyme(s), Genetics, Growth, Mortality, Physiology
NematodesandFlatworms Population
Phytoplankton Biochemistry, Development, Physiology, Population
TerrestrialPlants Growth
Zooplankton Accumulation, Behavior, Enzyme(s), Genetics, Intoxication, Mortality, Population, Reproduction
~ Un-Assigned Enzyme(s), Immunological, Mortality, Physiology, Population
View All Aquatic Ecotoxicity Studies and References
 
Summary of Acute Toxicity for Organism Group
Organism Group Average Acute Toxicity Acute Toxicity Range
Amphibians Slightly Toxic Slight Toxicity
Crustaceans Moderately Toxic Moderate Toxicity
Fish Slightly Toxic Not Acutely Toxic to Moderate Toxicity
Zooplankton Slightly Toxic Slight to Very High Toxicity
~ Un-Assigned Slightly Toxic Not Acutely Toxic to Slightly Toxic
View All Acute Summaries
 

Terrestrial Ecotoxicity

We are seeking funding to incorporate terrestrial ecotoxicity data analogous to the aquatic ecotoxicity data in the space above. Watch this space!

Related Chemicals for Glyphosate
CAS Number Relation Reason Chemical Name Chem Detail Registration Symptoms California Use Chem Use Type U.S. EPA Reg PAN Bad Actor
1071-83-6 Parent P Glyphosate View View View View Herbicide Yes Not Listed
1066-51-9 Related 5a (Aminomethyl)phosphonic acid View View View View Breakdown product No Not Listed
114370-14-8 Related 1 Glyphosate, diammonium salt View View View View Herbicide Yes Not Listed
Related 1 Glyphosate, dimethylammonium salt View View View View Herbicide Yes Not Listed
Related 1 Glyphosate, ethanolamine salt View View View View Herbicide Yes Not Listed
38641-94-0 Related 1 Glyphosate, isopropylamine salt View View View View Herbicide Yes Not Listed
40465-66-5 Related 1 Glyphosate, monoammonium salt View View View View Herbicide Yes Not Listed
70901-12-1, 39600-42-5 Related 1 Glyphosate, potassium salt View View View View Herbicide Yes Not Listed
70393-85-0 Related 1 Glyphosate, sodium sesqui salt View View View View Herbicide No Not Listed
Related 1 Glyphosate, triethanolamine salt View View View View Herbicide No Not Listed
81591-81-3 Related 1 Glyphosate-trimesium View View View View Herbicide No Not Listed
 
Working with the Information on this Page

Click on underlined terms for definitions or go to the Pesticide Tutorial overview page.

Any underlined term with a book icon has additional information.

* Data marked with an asterisk indicates that this chemical is not explicitly listed on the corresponding list. Instead, it belongs to a group of chemicals that IS designated on the list. For example, if an agency assigns a classification of reproductive toxicant to "mercury compounds", that classification is applied to all mercury compounds in the PAN Pesticide database, which are then marked with an asterisk.

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Citation: Kegley, S.E., Hill, B.R., Orme S., Choi A.H., PAN Pesticide Database, Pesticide Action Network, North America (San Francisco, CA, 2010), http:www.pesticideinfo.org.
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