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Endosulfan - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information

Note: See Working with the Information on this Page section below for important notes about this data.

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Chemical ID
 Identifying information, including synonyms, ID numbers, use type, chemical classification, a link to a list of all products containing this chemical and a list of the top crops this pesticide is used on in California.
Poisoning Symptoms
 Signs and symptoms of poisoning, first aid, and links to treatment information for this chemical.
Toxicity
 Link to information on toxicity to humans, including carcinogenicity, reproductive and developmental toxicity, neurotoxicity, and acute toxicity.
Regulatory
 Links to world-wide registration status as well as regulatory information for the U.S. and California.
Water
 Water quality standards and physical properties affecting water contamination potential.
Ecotoxicity
 Toxicity to aquatic organisms.
Related Chems
 List of chemicals in the same family, including breakdown products, salts, esters, isomers, and other derivatives.
 

Chemical Identification and Use for Endosulfan
Basic Identification Information About This Chemical
Chemical Name: Endosulfan
CAS Number: 115-29-7
U.S. EPA PC Code: 079401
CA DPR Chem Code: 259
Molecular Weight: 406.9
Molecular Structure:
Use Type: Insecticide
Chem Class: Organochlorine
View Related Chemicals
 
Additional Resources About This Chemical Class and Use Type

See the Global Pesticide Resources page for many additional links.
Historical Use of this Chemical
Top five crops and sites for this pesticide in California
Head Lettuce   Tomatoes for Processing   Cotton   Cantaloupe   Leaf Lettuce  
View All Crops and Sites
 
Other Names for this Chemical
About Chemical Synonyms
.alpha.,.beta.-1,2,3,4,7,7-Hexachlorobicyclo(2.2.1)-2-heptene-5,6-bisoxymethylene sulfite , .alpha.,.beta.-1,2,3,4,7,7-Hexachlorobicyclo(2.2.1)hepten-2-bis(oxymethylon-5,6-)sulfite , .beta.-6,7,8,9,10,10-Hexachloro-1,5,5a,6,9,9a-hexahydro-endo-6,9-methano-2,4,3-benzodioxathiepin 3-oxide , 00259 (CA DPR Chem Code Text) , 00259 (CA DPR Chem Code) , 079401 (US EPA PC Code Text) , 1,4,5,6,7,7-Hexachloro-5-norbornene-2,3-dimethanol, cyclic sulfite , 115-29-7 (CAS number) , 115297 , 115297 (CAS number without hyphens) , 259 (CA DPR Chem Code) , 259 (CA DPR Chem Code) , 5-Norbornene-2,3-dimethanol, 1,4,5,6,7,7-hexachloro-, cyclic sulfite , 6,7,8,9,10-Hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepin-3-oxide , 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide , 79401 (US EPA PC Code) , Benzoepin , Beosit , BIO 5462 , Chlorthiepin , Crisulfan , Cyclodan , Endocel , Endosol , Endossulfam , Endossulf?o , Endosulfan , Endosulfan , ENDOSULFAN (MIXED ISOMERS) , Endosulfan (mixture of alpha and beta isomers) , Endosulfan 35EC , Endosulphan , Endoszulf?n , ENT-23979 , FMC 5462 , Hexachlorohexahydromethano-2,4,3-benzodioxathiepin-3-oxide , Hildan , HOE 2671 , Insectophene , Kop-Thiodan , Malix , NCI-C00566 , NIA 5462 , Niagara 5,462 , OMS 570 , SD 4314 , Sulfurous acid, cyclic ester with 1,4,5,6,7,7-hexachloro-5-norbornene-2,3-dimethanol , Thifor , Thimul , Thiodan
 
Products Containing This Chemical
Current and historic U.S. registered products
View U.S. Products All Products Currently Registered Products
 

Signs and Symptoms of Endosulfan Poisoning

NOTE! There may be other diseases and chemicals that have similar symptoms.

If you have a poisoning emergency in the United States call 1-800-222-1222.
If the victim has collapsed or is unconscious, call 911.

Endosulfan is a Organochlorine compound.

Report a Poisoning
Symptoms of Poisoning with Organochlorine Compounds
Find Products Containing this Chemical

- Hypersensitive to stimulation, sensation of prickling, tingling or creeping on skin.
- Headache, dizziness, nausea, vomiting, incoordination, tremor, mental confusion, hyperexcitable state.
- In severe cases: convulsions, seizures, coma and respiratory depression.

Source for Group Symptoms: Recognition and Management of Pesticide Poisoning, 5th edition, U.S. EPA, Chapter 6.
Treatment for Organochlorine Poisoning

See: Recognition and Management of Pesticide Poisoning, 5th edition, U.S. EPA, Chapter 6, page 58.

 
Symptoms of Endosulfan Exposure from the International Chemical Safety Cards (ICSC)

Report a Poisoning
View full ICSC Cards: English   Español   Française   Chinese   Dutch   Finnish   German   Hungarian   Japanese   Swahili   Thai   Urdu  
NOTE! PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!
 General First Aid: IN ALL CASES CONSULT A DOCTOR!

Route of Exposure

Symptoms

First Aid
Inhalation (See Ingestion). Fresh air rest. Refer for medical attention.
Skin MAY BE ABSORBED! (See Ingestion). Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.
Eyes First rinse with plenty of water for several minutes (remove contact lenses if easily possible) then take to a doctor.
Ingestion Blue lips or fingernails. Confusion. Convulsions. Diarrhoea. Dizziness. Headache. Laboured breathing. Nausea. Unconsciousness. Vomiting. Weakness. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. Refer for medical attention.
Notes for ICSC Information
Use of alcoholic beverages enhances the harmful effect. If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s). Carrier solvents used in commercial formulations may change physical and toxicological properties. Do NOT take working clothes home. Beosit Chlortiepin Cyclodan Devisulphan Endocel Endosol Hildan Insectophene Malix Rasayansulfan Thifor Thimul Thiodan Thionex and Thiosulfan are trade names.
 

Toxicity Information for Endosulfan

  Note: Information for many chemicals is incomplete and may not be fully representative of effects on humans. Why?

Summary Toxicity Information

PAN Bad Actor
Chemical 1 		Acute
Toxicity 2 		Carcinogen Cholinesterase
Inhibitor 		Ground
Water Contaminant 		Developmental or
Reproductive Toxin 		Endocrine
Disruptor
Not Likely No
Suspected
 
Indicates high toxicity in the given toxicological category. Indicates no available weight-of-the-evidence summary assessment. For additional information on toxicity from scientific journals or registration documents, see the "Additional Resources for Toxicity " section of the chemical detail page.
1. PAN Bad Actors are chemicals that are one or more of the following: highly acutely toxic, cholinesterase inhibitor, known/probable carcinogen, known groundwater pollutant or known reproductive or developmental toxicant. NOTE! Because there are no authoritative lists of Endocrine Disrupting (ED) chemicals, EDs are not yet considered PAN Bad Actor chemicals.
2. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above.

Additional Resources about the Toxicity of this Chemical

See the Global Pesticide Resources page for many additional links.

Detailed Toxicity Information
Acute Toxicity 2
 Endosulfan
WHO Acute Hazard
TRI Acute Hazard
Material Safety Data Sheets
Acute rating from U.S. EPA product label
U.S. NTP Acute Toxicity Studies
      View Studies
Cholinesterase Inhibitor		 II, Moderately Hazardous
Not Listed
Not Available
Highly Toxic
Moderately to Highly Toxic

No
2. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above.
 
Cancer Information
 Endosulfan
IARC Carcinogens
U.S. NTP Carcinogens
California Prop 65 Known Carcinogens
U.S. EPA Carcinogens
TRI Carcinogen		 Not Listed
Not Listed
Not Listed
Not Likely
Not Listed
 
Endocrine Disruption
 Endosulfan
Illinois EPA list
Keith list
Colborn list
Benbrook list
Danish Inert list
EU list		 Known
Yes
Yes
Yes
Not listed
Yes
 
Reproductive and Developmental Toxicity
 Endosulfan
CA Prop 65 Developmental Toxin
U.S. TRI Developmental Toxin
CA Prop 65 Female Reproductive Toxin
CA Prop 65 Male Reproductive Toxin
U.S. TRI Reproductive Toxin 		Not Listed
Not Listed
Not Listed
Not Listed
Not Listed
 
Chemicals of Special Concern
 Endosulfan
PAN Bad Actors
PAN Dirty Dozen list		 Yes
 

Water Pollution Potential and Criteria for Endosulfan

Water Pollution Potential

PAN Ground Water Contaminant Rating Insufficient Data
 
Physical Property Data Related to Water Contamination Potential
Water Solubility (Avg, mg/L)
Adsorption Coefficient (Koc)
Hydrolysis Half-life (Avg, Days)
Aerobic Soil Half-life (Avg, Days)
Anaerobic Soil Half-life (Avg, Days) 		0.32
12,400
-
27.0
- 		 
 

Water Standards and Criteria
WHO Water Quality Criteria
Description Occurs in drinking-water at concentrations well below those at which toxic effects may occur
Notes Notes: n
Canadian Water Quality Guidelines for the Protection of Aquatic Life
 µg/L unless noted  
Fresh Water Guidelines .02
Salt Water Guidelines
 

Regulatory Information for Endosulfan

International Regulatory Status
Registration in Selected Countries Registration in Selected Countries:
Endosulfan
 
UNEP Persistent Organic Pollutant (POP)
UNEP Prior Informed Consent Chemical (PIC)
WHO Obsolete Pesticide		 Under Review

Not Listed
 

U.S. and California Regulatory Status
U.S. EPA Registered
U.S. EPA Hazardous Air Pollutant
U.S. EPA Minimum Risk Pesticide (25b list)

CA Registered
CA Groundwater Contaminant
CA Toxic Air Contaminant 		Yes
Not Listed
No

Yes
Not Listed
TAC
 

Maximum Tolerance and Residue Levels
Codex Alimentarius
   (UN FAO Maximum Residue Limits)
U.S. Maximum Tolerance Levels
European Union Maximum Residue Levels 		Go to web site

Go to web site
Go to web site
 

Ecotoxicity for Endosulfan

Note! Information for many chemicals is incomplete and may not be fully representative of effects on the environment. Why? Click on underlined terms for definitions and additional information.

Aquatic Ecotoxicity
All Toxic Effects for Organism Group
Organism Group Effects Noted
Amphibians Avoidance, Behavior, Development, Feeding Behavior, Growth, Histology, Hormone(s), Morphology, Mortality, Physiology, Population, Reproduction
Annelida Accumulation, Behavior, Mortality, Population
AquaticPlants Accumulation, Biochemistry, Enzyme(s), Physiology, Population
Cnidaria Mortality, Population, Reproduction
Crustaceans Accumulation, Biochemistry, Cell(s), Development, Enzyme(s), Genetics, Growth, Histology, Intoxication, Mortality, No Effect Coded, Physiology, Population, Reproduction
Echinoderms Development, Intoxication, Mortality, Reproduction
Fish Accumulation, Behavior, Biochemistry, Cell(s), Development, Enzyme(s), Feeding Behavior, Genetics, Growth, Histology, Hormone(s), Immunological, Intoxication, Morphology, Mortality, No Effect Coded, Physiology, Population, Reproduction
Fungi Development, Reproduction
Insects Behavior, Development, Enzyme(s), Feeding Behavior, Genetics, Growth, Histology, Intoxication, Morphology, Mortality, Population
MarineBenthicCommunity Mortality
Molluscs Accumulation, Biochemistry, Development, Enzyme(s), Genetics, Growth, Histology, Intoxication, Morphology, Mortality, Physiology, Population, Reproduction
NematodesandFlatworms Population
Phytoplankton Accumulation, Biochemistry, Enzyme(s), Growth, Mortality, Physiology, Population, Reproduction
Zooplankton Accumulation, Behavior, Biochemistry, Development, Enzyme(s), Feeding Behavior, Genetics, Growth, Hormone(s), Intoxication, Morphology, Mortality, Physiology, Population, Reproduction
~ Un-Assigned Behavior, Biochemistry, Development, Enzyme(s), Feeding Behavior, Genetics, Growth, Mortality, Physiology, Population, Reproduction
~Un-Assigned Population
View All Aquatic Ecotoxicity Studies and References
 
Summary of Acute Toxicity for Organism Group
Organism Group Average Acute Toxicity Acute Toxicity Range
Amphibians Moderately Toxic Moderate to Very High Toxicity
Annelida Moderately Toxic Moderate to High Toxicity
Cnidaria Highly Toxic Highly Toxic
Crustaceans Highly Toxic Moderate to Very High Toxicity
Echinoderms Very Highly Toxic Very Highly Toxic
Fish Very Highly Toxic High to Very High Toxicity
Insects Highly Toxic Moderate to Very High Toxicity
MarineBenthicCommunity Very Highly Toxic Very Highly Toxic
Molluscs Moderately Toxic Slight to Very High Toxicity
Phytoplankton Moderately Toxic Moderate Toxicity
Zooplankton Highly Toxic Moderate to Very High Toxicity
~ Un-Assigned Very Highly Toxic High to Very High Toxicity
View All Acute Summaries
 

Terrestrial Ecotoxicity
Summary of Acute Toxicity for Organism Group
Organism Group Average Acute Toxicity Acute Toxicity Range
HoneybeesModerately ToxicModerately Toxic
Note: Population-level effects on honeybees may occur even if a pesticide has low acute toxicity. For example, certain pesticides interfere with honeybee reproduction, ability to navigate, or temperature regulation, any of which can have an effect on long-term survival of honeybee colonies. The neonicotinoids, pyrethroids and keto-enol pesticides are some types of pesticides causing one or more of these effects.
Honeybee Chronic Toxicity

Sorry, no honeybee chronic toxicity data available for this chemical. Try related chemicals.

Related Chemicals for Endosulfan
CAS Number Relation Reason Chemical Name Chem Detail Registration Symptoms California Use Chem Use Type U.S. EPA Reg PAN Bad Actor
115-29-7 Parent P Endosulfan View View View View Insecticide Yes Yes
115-28-6 Related 5a Chlorendic Acid View View View View Breakdown product No Yes
959-98-8 Related 6 Endosulfan I (alpha) View View View View Insecticide No Yes
33213-65-9 Related 6 Endosulfan II (beta) View View View View Insecticide No Yes
1031-07-8 Related 2 Endosulfan sulfate View View View View Breakdown product No Not Listed
Related 13 Endosulfans Total View View View View Insecticide No Not Listed
 
Working with the Information on this Page

Click on underlined terms for definitions or go to the Pesticide Tutorial overview page.

Any underlined term with a book icon has additional information.

* Data marked with an asterisk indicates that this chemical is not explicitly listed on the corresponding list. Instead, it belongs to a group of chemicals that IS designated on the list. For example, if an agency assigns a classification of reproductive toxicant to "mercury compounds", that classification is applied to all mercury compounds in the PAN Pesticide database, which are then marked with an asterisk.

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Citation: Kegley, S.E., Hill, B.R., Orme S., Choi A.H., PAN Pesticide Database, Pesticide Action Network, North America (San Francisco, CA, 2010), http:www.pesticideinfo.org.
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