PAN Pesticides Database - Chemicals

Methoprene - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information

Note: See Working with the Information on this Page section below for important notes about this data.

This website and underlying databases are maintained and updated by Pesticide Action Network North America (PAN). The project is made possible by our Sponsors and by PAN general funds. We need your support to maintain and improve this system. Please support the database and website — donate to PANNA.

Identifying information, including synonyms, ID numbers, use type, chemical classification, a link to a list of all products containing this chemical and a list of the top crops this pesticide is used on in California.
Signs and symptoms of poisoning, first aid, and links to treatment information for this chemical.
Link to information on toxicity to humans, including carcinogenicity, reproductive and developmental toxicity, neurotoxicity, and acute toxicity.
Links to world-wide registration status as well as regulatory information for the U.S. and California.
Water quality standards and physical properties affecting water contamination potential.
Toxicity to aquatic organisms.
List of chemicals in the same family, including breakdown products, salts, esters, isomers, and other derivatives.

Chemical Identification and Use for Methoprene

Basic Identification Information About This Chemical
Chemical Name: Methoprene
CAS Number: 40596-69-8
U.S. EPA PC Code: 105401
549500 (Old US EPA PC Code.)
549500 (Old US EPA PC Code.)
CA DPR Chem Code: 1784
Molecular Weight: 310.47
Use Type: Insect Growth Regulator
Chem Class: Juvenile hormone mimic
View Related Chemicals
Additional Resources About This Chemical Class and Use Type
Historical Use of this Chemical
Top five crops and sites for this pesticide in California
Public Health Pest Control   Structural Pest Control   Regulatory   Landscape   Aquatic Area  
View All Crops and Sites
Other Names for this Chemical
About Chemical Synonyms
(2E,4E)-11-Methoxy-3,7,11-trimethyl-2,4-dodecadienoic acid 1-methylethyl ester , 01784 (CA DPR Chem Code Text ) , 1-Methylethyl (E,E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate , 105401 [US EPA PC Code, Numeric ] , 105401 [US EPA PC Code, Text ] , 1784 (CA DPR Chem Code) ) , 2,4-Dodecadienoic acid, 11-methoxy-3,7,11-trimethyl-, 1-methylethyl ester, (E,E)- , 2,4-Dodecadienoic acid, 11-methoxy-3,7,11-trimethyl-, ispropyl ester, (E,E)- , 40596-69-8 (CAS number) , 40596698 , 40596698 (CAS number without hyphens) , 549500 (Old US EPA PC Code) , 549500 [US EPA PC Code, Numeric ] , 549500 [US EPA PC Code, Text ] , ACV (PDP Code) , Altosid Briquets , Altosid CP10 , Altosid SR 10 , ENT-70460 , Isopropyl (2E,4E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate , Isopropyl (2E,4E)-11methoxy-3,7,11-trimethyl-2-4 dodecadienoate , Isopropyl (2E,4E)-11methoxy-3,7,11-trimethyl-2-4 dodecadienoate (methoprene) , Isopropyl (E,E)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate , Kabat , Manta , Methopreen , Methopren , Methoprene , Methoprene (ANSI) , Methoprene Isopropyl , Methoprene RED , Methoprene RED Update , Metopreno , OMS 1697 , Use code no. 105401 , ZR-515
Products Containing This Chemical
Current and historic U.S. registered products
View U.S. Products All Products Currently Registered Products

Signs and Symptoms of Methoprene Poisoning

NOTE! There may be other diseases and chemicals that have similar symptoms.

If you have a poisoning emergency in the United States call 1-800-222-1222.
If the victim has collapsed or is unconscious, call 911.

Symptoms of Methoprene Exposure

Source for Symptoms: Biopesticide Fact Sheet. Biopesticides and Pollution Prevention Division, U.S. EPA, Washington, D.C. December 2001. (EPA Other)


Toxicity Information for Methoprene

  Note: Information for many chemicals is incomplete and may not be fully representative of effects on humans. Why?

Summary Toxicity Information

PAN Bad Actor
Carcinogen Cholinesterase
Water Contaminant
Developmental or
Reproductive Toxin
Not Listed Not Acutely Toxic Not Likely No
Indicates high toxicity in the given toxicological category. Indicates no available weight-of-the-evidence summary assessment. For additional information on toxicity from scientific journals or registration documents, see the "Additional Resources for Toxicity " section of the chemical detail page.
1. PAN Bad Actors are chemicals that are one or more of the following: highly acutely toxic, cholinesterase inhibitor, known/probable carcinogen, known groundwater pollutant or known reproductive or developmental toxicant. NOTE! Because there are no authoritative lists of Endocrine Disrupting (ED) chemicals, EDs are not yet considered PAN Bad Actor chemicals.
2. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above.

Detailed Toxicity Information

Acute Toxicity 2
WHO Acute Hazard
TRI Acute Hazard
Material Safety Data Sheets
Acute rating from U.S. EPA product label
U.S. NTP Acute Toxicity Studies
      View Studies
Cholinesterase Inhibitor
U, Unlikely to be Hazardous
Not Listed
Not Available
No Consensus Value
No NTP Studies

2. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above.
Cancer Information
IARC Carcinogens
U.S. NTP Carcinogens
California Prop 65 Known Carcinogens
U.S. EPA Carcinogens
TRI Carcinogen
Not Listed
Not Listed
Not Listed
Not Likely
Not Listed
Endocrine Disruption
Illinois EPA list
Keith list
Colborn list
Benbrook list
Danish Inert list
EU list
Not Listed
Not Listed
Not Listed
Not Listed
Not Listed
Not Listed
Reproductive and Developmental Toxicity
CA Prop 65 Developmental Toxin
U.S. TRI Developmental Toxin
CA Prop 65 Female Reproductive Toxin
CA Prop 65 Male Reproductive Toxin
U.S. TRI Reproductive Toxin
Not Listed
Not Listed
Not Listed
Not Listed
Not Listed
Chemicals of Special Concern
PAN Bad Actors
PAN Dirty Dozen list
Not Listed
Not Listed

Water Pollution Potential and Criteria for Methoprene

Water Pollution Potential

PAN Ground Water Contaminant Rating Insufficient Data
Physical Property Data Related to Water Contamination Potential
Water Solubility (Avg, mg/L)
Adsorption Coefficient (Koc)
Hydrolysis Half-life (Avg, Days)
Aerobic Soil Half-life (Avg, Days)
Anaerobic Soil Half-life (Avg, Days)

Water Standards and Criteria

WHO Water Quality Criteria
Description Not considered appropriate to set guideline values for pesticides used for vector control in drinking-water
Notes Notes: n
Canadian Water Quality Guidelines for the Protection of Aquatic Life
g/L unless noted  
Fresh Water Guidelines 0.09 (Target Organism Management value: 0.53) Notes: c,j,cc
Salt Water Guidelines Insufficient data

Regulatory Information for Methoprene

International Regulatory Status

UNEP Persistent Organic Pollutant (POP)
UNEP Prior Informed Consent Chemical (PIC)
WHO Obsolete Pesticide
Not Listed
Not Listed
Not Listed

U.S. and California Regulatory Status

U.S. EPA Registered
U.S. EPA Hazardous Air Pollutant
U.S. EPA Minimum Risk Pesticide (25b list)

CA Registered
CA Groundwater Contaminant
CA Toxic Air Contaminant
Not Listed

Not Listed
Not Listed

Maximum Tolerance and Residue Levels

Codex Alimentarius
   (UN FAO Maximum Residue Limits)
U.S. Maximum Tolerance Levels
European Union Maximum Residue Levels
Go to web site

Go to web site

Go to web site

Ecotoxicity for Methoprene

Note! Information for many chemicals is incomplete and may not be fully representative of effects on the environment. Why? Click on underlined terms for definitions and additional information.

Aquatic Ecotoxicity

All Toxic Effects for Organism Group
Organism Group Effects Noted
Amphibians Behavior, Development, Growth, Morphology, Mortality, Population
Annelida Mortality, Population
Crustaceans Behavior, Biochemistry, Development, Enzyme(s), Growth, Mortality, Physiology, Population
Fish Accumulation, Behavior, Biochemistry, Development, Growth, Morphology, Mortality, Population
Insects Avoidance, Development, Growth, Morphology, Mortality, Population, Reproduction
Molluscs Intoxication, Mortality, Population
NematodesandFlatworms Feeding Behavior, Mortality, Population, Reproduction
Phytoplankton Physiology
TerrestrialPlants Population
Zooplankton Development, Enzyme(s), Growth, Intoxication, Morphology, Mortality, Physiology, Population, Reproduction
~ Un-Assigned Development, Growth, Mortality, Population, Reproduction
View All Aquatic Ecotoxicity Studies and References
Summary of Acute Toxicity for Organism Group
Organism Group Average Acute Toxicity Acute Toxicity Range
Annelida Not Acutely Toxic Not Acutely Toxic
Crustaceans Highly Toxic Highly Toxic
Fish Slightly Toxic Not Acutely Toxic to Moderate Toxicity
Insects Very Highly Toxic Very Highly Toxic
Molluscs Slightly Toxic Slight Toxicity
Zooplankton Moderately Toxic Slight to Very High Toxicity
~ Un-Assigned Slightly Toxic Slight Toxicity
View All Acute Summaries

Terrestrial Ecotoxicity

Summary of Acute Toxicity for Organism Group

Sorry, no honeybee acute toxicity data available for this chemical. Try related chemicals.

Note: Population-level effects on honeybees may occur even if a pesticide has low acute toxicity. For example, certain pesticides interfere with honeybee reproduction, ability to navigate, or temperature regulation, any of which can have an effect on long-term survival of honeybee colonies. The neonicotinoids, pyrethroids and keto-enol pesticides are some types of pesticides causing one or more of these effects.
Honeybee Chronic Toxicity
Organism Group Chronic Toxicity  

Related Chemicals for Methoprene

CAS Number Relation Reason Chemical Name Chem Detail Symptoms California Use Chem Use Type U.S. EPA Reg PAN Bad Actor
40596-69-8 Parent P Methoprene View View View Insect Growth Regulator No Not Listed
Related 5a Methoprene acid View View View Breakdown product No Not Listed
65733-16-6 Related 6 S-Methoprene View View View Insect Growth Regulator Yes Not Listed
Working with the Information on this Page

Click on underlined terms for definitions or go to the Pesticide Tutorial overview page.

Any underlined term with a book icon has additional information.

* Data marked with an asterisk indicates that this chemical is not explicitly listed on the corresponding list. Instead, it belongs to a group of chemicals that IS designated on the list. For example, if an agency assigns a classification of reproductive toxicant to "mercury compounds", that classification is applied to all mercury compounds in the PAN Pesticide database, which are then marked with an asterisk.

To print this page, choose Print. To export this data, choose Save As 'HTML Source' and open it in Excel or equivalent program.